Beilstein J. Org. Chem.2020,16, 3093–3103, doi:10.3762/bjoc.16.259
19, Kamala Nehru Nagar, Ghaziabad, UP-201002, India 10.3762/bjoc.16.259 Abstract A convenient practical approach for the synthesis of 2-(pyridin-2-yl)ethanols by direct benzylicaddition of azaarenes and aldehydes under catalyst- and solvent-free conditions is reported. This reaction is metal-free
azaarene derivatives under neat conditions through a highly atom-economical pathway. To evaluate the preparative potential of this process, gram-scale reactions were performed up to a 10 g scale.
Keywords: aldehydes; azaarenes; benzylicaddition; green chemistry; solvent-free conditions; Introduction
atom economy and reduces large amounts of waste generated by the unnecessary utilization of catalysts and solvents. Notably, this reaction is compatible with a gram scale, and further research is yet to be developed towards more sustainability.
Benzylicaddition of aldehydes to azaarenes using
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Graphical Abstract
Scheme 1:
Benzylic addition of aldehydes to azaarenes using different catalysts.